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End of fillings in sight as scientists find Alzheimer's drug makes teeth grow back

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  • End of fillings in sight as scientists find Alzheimer's drug makes teeth grow back

    Fillings could be consigned to history after scientists discovered that a drug already trialled in Alzheimer's patients can encourage tooth regrowth and repair cavities.


    illings could be consigned to history after scientists discovered that a drug already trialled in Alzheimer's patients can encourage tooth regrowth and repair cavities.

    Researchers at King's College London found that the drug Tideglusib stimulates the stem cells contained in the pulp of teeth so that they generate new dentine – the mineralised material under the enamel.

    Teeth already have the capability of regenerating dentine if the pulp inside the tooth becomes exposed through a trauma or infection, but can only naturally make a very thin layer, and not enough to fill the deep cavities caused by tooth decay.


    Scientists showed it is possible to soak a small biodegradable sponge with the drug and insert it into a cavity, where it triggers the growth of dentine and repairs the damage within six weeks.

    The tiny sponges are made out of collagen so they melt away over time, leaving only the repaired tooth.

    This is an extremely interesting and novel approach which shows great promise and we will look forward to it being translated into clinical application
    Dr Nigel Carter, CEO of the Oral Health Foundation

    Professor Paul Sharpe, lead author of the study, of the Dental Institute, from King’s College London, said: “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.

    “In addition, using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”

    Currently dentists use man-made cements or fillings, such as calcium and silicon-based products, to treat larger cavities and fill holes in teeth.

    But this cement remains in the tooth and fails to disintegrate, meaning that the normal mineral level of the tooth is never completely restored.


    However the new technique could reduce the need for fillings of cements, which are prone to infection and often need replacing a number of times.

    When fillings fail or infection occurs, dentists have to remove and fill an area that is larger than what is affected, and after multiple treatments the tooth may eventually need to be extracted.

    Dr Nigel Carter, CEO of the Oral Health Foundation: “This is an extremely interesting and novel approach which shows great promise and we will look forward to it being translated into clinical application that could undoubtedly be a progressive step in the treatment of dental disease.

    “While fillings have remained highly effective in repairing large cavities, they are susceptible to wear-and-tear and can occasionally be in need of repair and replacement. This presents problems as the dentist could have to remove and fill a larger area each time and after numerous treatments the tooth may then have to be extracted.

    “Creating a more natural way for the tooth to repair itself could not only eliminate these issues, but also be a far less invasive treatment option for patients. With dental phobia still being very common, using a natural way to stimulate the renewal of dentine could be an especially comforting proposal for these groups, for which undergoing treatment can often be a cause great anxiety.”

    The procedure has so far only been used in mouse teeth, but it was shown to 'fill the whole injury site'.

    And Tideglusib has already been shown to be safe in clinical trials of patients with Alzheimer's disease so scientists say that the treatment could be fast-tracked into dental practices.

    The research was published in the journal Scientific Reports.
    I wear a Fez. Fez-es are cool

  • #2
    Doesnt sound like there could be any other possible side effects.

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    • #3

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      • #4
        I'm no doctor or dentist, but since fillings are (most?) often used on young patients what are the potential side effects of using an old-timers cognition drug on younger folks still-developing brains?

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        • #5
          I knew it! I knew if I just waited long enough I wouldn't have to let those bastards use their drills on my freakin' teeth
          WH

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          • #6
            Eventually they'll just pump that shit into the water and cut out the middlemen.

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            • #7
              Originally posted by Chili View Post
              Eventually they'll just pump that shit into the water and cut out the middlemen.
              "Fluoridation is the most monstrously conceived and dangerous communist plot we have ever had to face!

              Mandrake, do you realize that in addition to fluoridating water, why, there are studies underway to fluoridate salt, flour, fruit juices, soup, sugar, milk... ice cream. Ice cream, Mandrake, children's ice cream.

              You know when fluoridation first began?

              Nineteen hundred and forty-six. 1946, Mandrake. How does that coincide with your post-war Commie conspiracy, huh? It's incredibly obvious, isn't it? A foreign substance is introduced into our precious bodily fluids without the knowledge of the individual. Certainly without any choice. That's the way your hard-core Commie works."


              - General Jack D. Ripper

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              • #8
                Originally posted by Strychnine View Post
                "Fluoridation is the most monstrously conceived and dangerous communist plot we have ever had to face!

                Mandrake, do you realize that in addition to fluoridating water, why, there are studies underway to fluoridate salt, flour, fruit juices, soup, sugar, milk... ice cream. Ice cream, Mandrake, children's ice cream.

                You know when fluoridation first began?

                Nineteen hundred and forty-six. 1946, Mandrake. How does that coincide with your post-war Commie conspiracy, huh? It's incredibly obvious, isn't it? A foreign substance is introduced into our precious bodily fluids without the knowledge of the individual. Certainly without any choice. That's the way your hard-core Commie works."


                - General Jack D. Ripper
                I hadn't thought about it before, but that quote could have been written for the Rick Sanchez character in Rick and Morty.. Sounds just like his type of dialog!

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                • #9
                  What is the big deal with fluoride...seriously? Has anyone died from drinking water or brushing their teeth? No.

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                  • #10
                    Originally posted by GeorgeG. View Post
                    What is the big deal with fluoride...seriously? Has anyone died from drinking water or brushing their teeth? No.
                    If they want to make you docile, they don't want you dead
                    I wear a Fez. Fez-es are cool

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                    • #11
                      Sounds like they accidentally found an Alzheimer’s drug while trying to cure meth mouth.

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                      • #12
                        Originally posted by GeorgeG. View Post
                        What is the big deal with fluoride...seriously? Has anyone died from drinking water or brushing their teeth? No.
                        I don't give a shit personally, except that I'm generally opposed to the government adding stuff to my food or drink in a less than transparent way. Especially for something as random as tooth care..

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                        • #13
                          I bet the English are really happy.
                          Originally posted by racrguy
                          What's your beef with NPR, because their listeners are typically more informed than others?
                          Originally posted by racrguy
                          Voting is a constitutional right, overthrowing the government isn't.

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                          • #14
                            Mary Newport M.D. published a book called Alzheimer's Disease, What if there was a cure. The story of Ketones.

                            Alzheimer's runs in the females of my wife's family. It scares me to think of watching her mother go through it after seeing her grandmother suffer a few years before passing away. Scares me even more to think of my wife that way. So a year ago I stumbled on ketones and read that it may not cure but the Alzheimer's disease needed glucose to grow in their brain. A ketogenic diet prevents the presence of glucose there. As I know it. I'm waiting for the book to arrive.

                            Sent from my SM-G955U using Tapatalk
                            Fuck you. We're going to Costco.

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                            • #15
                              One of the benefits I realized by adopting an Atkins/Paleo style of eating for the past 6-7 years was keeping my blood glucose levels in check. Otherwise I easily go pre-diabetic. High glucose levels can contribute to numerous health issues, Alzheimer's being among them. My dad's side of the family had or likely had Alhzeimer's sufferers, so earlier this year I had genetic testing done for the APOE4 gene that is associated with late-onset Alhzeimer's. I had asked my PCP about it beforehand, and she did not completely endorse having it on the basis that it is only associated with the disease, and if you do carry it there is no guarantee you'll get it if you live long enough or any real prevention plan other than a healthy lifestyle. Turned out I do not carry it, but if I had I would have simply doubled down on healthy living and making absolutely sure my LTC policy was maintained.

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